Effectiveness of Autologous Platelet-rich Plasma on Knee Cartilage Injury

• Status: Completed
• Trial end date: 2016-05-01
• Target enrollment: 0
• Participant gender: All

Summary

To analyze the effectiveness of intra-articular injection of autologous PRP on knee cartilage repair and evaluating functional recovery of the knee joint in knee cartilage injury patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese PLA General Hospital

Criteria

Inclusion Criteria:

• Knee cartilage injury

• Having normal and stable joint motion but no deformity

• Focal cartilage defects confirmed by magnetic resonance imaging (MRI), Outerbridge classification III/IV with a defect size < 10 cm2 graded as Outerbridge II at maximum

• Focal articular cartilage injury in the knee

• 14-55 years of age

• Provision of signed informed consent to participate in the trial

Exclusion Criteria:

• Poor general condition

• Blood diseases

• Use of local hormone treatment within 3 months before the trial

• Bleeding tendency

• Drug addiction, including anesthetic, alcohol and poison

• Inflammatory arthropathy, including specific and non-specific arthritis and severe osteoarthritis

• Contagious viral infection

• Metabolic diseases, such as gout and rheumatism

• Pregnant or lactating, or planning to become pregnant within 1 year after the initial registration

• Unable to cooperate with rehabilitation therapy because of psychological/mental disorders