Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Smoking is often a problem for alcohol dependent individuals. Many people who seek treatment for alcohol dependence are unable to quit smoking. The purpose of this study is to evaluate the effectiveness of bupropion, an antidepressant medication, in treating smokers receiving treatment for alcohol dependence.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Bupropion

Criteria

Inclusion Criteria:

• Smokes a minimum of 10 cigarettes daily for at least 1 year prior to study entry

• Abstinence from alcohol and other non-nicotine drugs for between 1 and 12 months at time of study entry

• Meets criteria for alcohol dependence or abuse in the 12 months prior to study entry

Exclusion Criteria:

• History of seizures, head trauma and/or severe hepatic cirrhosis

• Current use of medications known to affect smoking behavior and/or cessation

• Use of tricyclic antidepressant medication and monoamine oxidase inhibitors

• Major depressive disorder within the month prior to study entry

• Eating disorder within the year prior to study entry

• History of bipolar or psychotic disorder

• Pregnant or breastfeeding

• Unstable serious medical disorder

• History of migraines

• Currently using smokeless tobacco, pipes, or cigars