Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia

• Status: Not yet recruiting
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this trial is to compare the effectiveness of labor analgesia with clonidine, dexmedetomidine, or fentanyl (standard care) adjuncts.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Grace Lim, MD, MS
• Treatments: Clonidine; Dexmedetomidine; Fentanyl; Ropivacaine

Criteria

Inclusion Criteria:

• >/= 18 years of age

• American Society of Anesthesiologists (ASA) Physical Status 2 or 3

• Term pregnancy (>37 gestational weeks)

• Planning epidural labor analgesia

• Singleton pregnancy

• Vertex presentation

• Planned vaginal delivery

Exclusion Criteria:

• Pre-eclampsia with or without severe features

• New initiation of antihypertensive agent within 24 hours prior to enrollment

• Uncontrolled systemic comorbidities [i.e., diabetes, hepatic, renal or cardiac]

• Known or suspected fetal abnormalities

• Allergy to study agents

• Contra-indication to neuraxial anesthesia

• Inability to communicate or participate in study procedures