Effectiveness of Depression Treatment Following Coronary Artery Bypass Surgery

• Status: Completed
• Trial end date: 2009-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to treat depression in patients who have undergone coronary artery bypass graft (CABG).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Pittsburgh
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)

Criteria

Inclusion Criteria:

• Recently underwent CABG (combined or redo procedure) at one of 8 Pittsburgh area study hospitals

• A PHQ score greater than 10 OR if nondepressed control, a PHQ score less than 5 at both 2 days post CABG to the date of discharge following CABG and when reassessed 2 weeks after hospital discharge

• Folstein Mini-Mental State Examination (MMSE) score greater than or equal to 24

• Able to be evaluated and treated for depression as an outpatient post CABG

• Has a household telephone

Exclusion Criteria:

• Presently in treatment with a mental health specialist

• Actively suicidal

• History of psychotic illness

• History of bipolar illness according to subject self-report and past medical history

• Current alcohol dependence or other substance abuse as evidenced by chart review and the CAGE questionnaire

• Organic mood syndromes, including those secondary to medical illness or drugs

• Presence of non-cardiovascular conditions that are likely to be fatal within 1 year

• Unstable medical condition as indicated by history, physical, and/or laboratory findings

• Previous enrollment in the study cohort

• Non-English speaking, illiterate, or possessing any other communication barrier

• If nondepressed control, current or previous diagnosis or treatment of depression