Effectiveness of Efavirenz-based Regimen in HIV-1-infected Patients With Nevirapine Hypersensitivity

• Status: Completed
• Trial end date: 2010-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The primary objective of this study is to compare the effectiveness of EFV-based regimens in HIV-1-infected patients who; (1) were previously allergic to NVP and stopped all ARV simultaneously; (2) were previously allergic to NVP and continued the other NRTIs for a period of time, i.e. "staggered interruption"; and (3) started EFV-based regimens as an initial regimen (as controlled group).

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Bamrasnaradura Infectious Diseases Institute
• Collaborators: Clinical Research Collaborative Network; Thai Red Cross AIDS Research Centre
• Treatments: Efavirenz; Nevirapine

Criteria

Inclusion Criteria:

• age 18-70 years old

• documented HIV infection

• started EFV-based regimens between January 2002 and December 2008 at Bamrasnaradura Infectious Diseases Institute

Exclusion Criteria:

• previously received non-HAART regimens such as dual NRTIs regimen, AZT monotherapy with single-dose NVP in pregnancy patients

• previously received protease inhibitor-based regimen

• diseases or conditions that significantly affected either kidney or liver functions such as decompensated liver cirrhosis, ESRD