Effectiveness of Epidermal Growth Factor-containing Ointment on the Solar Lentigines
Status:
Completed
Trial end date:
2018-12-26
Target enrollment:
Participant gender:
Summary
Subjects were randomly assigned to groups for treatment with either an EGF-containing
ointment (the study group) or the vehicle alone (petrolatum; the control group). The EGF
ointment included recombinant human EGF (1 μg/g). Random numbers used for assignment to
groups were provided by the randomization function of SAS.
The subjects received one session of laser treatment with a Q-switched (QS) 532-nm Nd:yttrium
aluminum garnet (YAG) laser of their solar lentigines after enrollment. . The end point of
laser treatment for lentigines was immediate whitening. The subjects then applied the EGF
ointment or vehicle twice daily (morning and evening) to the lesion for 4 weeks after laser
treatment.