Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine
Status:
Completed
Trial end date:
2005-05-01
Target enrollment:
Participant gender:
Summary
Cocaine abuse continues to represent a significant public-health concern. Cocaine likely
creates its addictive effects by increasing levels of dopamine, a chemical found in the
brain. GABA agonists are chemicals that have the opposite effect of cocaine by inhibiting the
release of dopamine. The purpose of this study is to determine whether GABA agonists reduce
the psychological and physiological reinforcing effects of cocaine.