Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery

• Status: Not yet recruiting
• Trial end date: 2023-07-31
• Target enrollment: 0
• Participant gender: All

Summary

Ischemia and reperfusion injury during free flap reconstructive surgery creates a state of increased oxidative stress that can adversely affect the flap outcomes. Ascorbic acid (AA) had been proven to have beneficial effect on end-organ protection and flap survival from ischemia-reperfusion injury via its antioxidant properties.

The investigators hypothesise that perioperative parenteral ascorbic acid treatment may reduce oxidative stress among participants undergoing free flap reconstructive surgery along with reduction in inflammatory markers, improved rate of flap viability and wound healing at both donor and recipient sites.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Malaya
• Treatments: Ascorbic Acid

Criteria

Inclusion Criteria:

• Adults (age 18 years and older, male or female) who are planned for elective free flap reconstructive surgery.

Exclusion Criteria:

• Hypersensitivity to vitamin C

• Oliguria (urine output <400mL/day) or anuria (urine output <100mL/day)

• Renal failure (serum creatinine level ≥175.0 %mol/L)

• Hemodialysis

• Renal calculi

• Thalassemia

• Glucose-6-phosphate dehydrogenase (G6PD) deficiency

• Unfit for surgery

• Pregnancy or lactating

• Hemochromatosis

• Hyperoxaluria