Effectiveness of Intermittent Preventive Treatment for Malaria in Children
Status:
Completed
Trial end date:
2006-12-01
Target enrollment:
Participant gender:
Summary
Intermittent preventive treatment for malaria in children (IPTc) is a promising new approach
to malaria control. Preliminary studies of IPTc in Senegal and Mali indicate that this
approach can be very effective. Although the results of these studies suggest that IPTc with
sulphadoxine-pyrimethamine (SP) plus artesunate (AS) or SP alone is an efficacious and safe
intervention for reducing the burden of malaria and anaemia in children in high transmission
areas with short transmission periods, there is no data from areas with long transmission
periods. This study aims to evaluate the effectiveness of IPTc in reducing anaemia and
malaria in an area with up to 6 months of transmission in Ghana. Two thousand two hundred
forty children aged 3-59 months will be randomly allocated to four groups (560 per arm) to
receive amodiaquine plus artesunate (AQ+AS), given at two different intervals (monthly or
bimonthly), SP or placebo. The children will also be followed to determine if there is any
rebound in the incidence of severe malaria and anaemia in the year following IPTc.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Gates Malaria Partnership London School of Hygiene and Tropical Medicine
Collaborator:
INDEPTH Network
Treatments:
Amodiaquine Artesunate Fanasil, pyrimethamine drug combination Pyrimethamine Sulfadoxine