Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2
Status:
Completed
Trial end date:
2007-05-01
Target enrollment:
Participant gender:
Summary
Cocaine is one of the most widely abused drugs in the United States. Memantine is a type of
drug called an NMDA receptor antagonist. It works by decreasing normal excitement in the
brain. NMDA receptor antagonists have shown to reduce cocaine-induced dopamine release in
animal models, as well as lessen conditioned cocaine cues. The purpose of this study is to
determine the effectiveness of memantine in preventing relapse to cocaine use in cocaine
dependent individuals. In addition, this study will determine whether memantine produces
better results than a placebo in decreasing cocaine craving, psychological symptoms,
functional impairment, and discontinuation of treatment in cocaine dependent individuals.
Phase:
Phase 2
Details
Lead Sponsor:
New York State Psychiatric Institute
Collaborators:
National Institute on Drug Abuse (NIDA) Research Foundation for Mental Hygiene, Inc.