Effectiveness of N-acetylcysteine on Preservation Solution During Liver Transplantation
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Evaluate the effectiveness of the administration produced antioxidant N-acetylcysteine (NAC),
decreasing the incidence of primary graft dysfunction and primary failure. The degree of
dysfunction will be monitored by the method of LIMON, metabonomics techniques and according
to the latest published validation Liver Transplantation (16 943-949 2010), total
billirrubina greater than 10 mg / dl, INR greater than 1.6 in the seventh postoperative day
and alanine or aspartate aminotransferase greater than 2000 IU / L in the first seven days.
Liver dysfunction is considered, the presence of a transaminase value> 2000 IU / L 1-7
postoperative day or BT> 10 mg / dl or INR> 1.6, both only in the 7th postoperative day
(Olthoff et al Liver Transplantation 16,943 -949 2010).