Effectiveness of New Analgesic Strategy Compared to the Usal Antalgic Strategy

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: Male

Summary

Quality of life of adult patients with sickle cell disease is deeply impaired by severe adverse medical events that inadvertently occur throughout their time life. Indeed, patients not presenting a life threatening condition often present to the emergency department with sickle cell disease crisis related pain. Currently, the effectiveness of specific analgesic strategies for treating sickle cell disease crisis related pain are mostly based on acetaminophen and opioid derivates combination along with oxygen delivery. Those strategies are effective but may last up to half an hour to obtain pain relief. This delay mostly depends on the availability of venous access and on individual patient response to treatment. Nitrous oxide is a volatile efficient analgesic therapy that has been repeatedly shown to allow rapid analgesia in the emergency department setting.

The investigators hypothesise that a new analgesic strategy (rapid optimized analgesic strategy) including nitrous oxide and nefopam would be as safe and more rapidly effective than current analgesic strategy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assistance Publique - Hôpitaux de Paris
• Treatments: Acetaminophen; Analgesics; Morphine; Nefopam; Nitrous Oxide

Criteria

Inclusion Criteria:

• male adult patient with sickle cell anemia,

• age ≥ 18 years,

• main complaint : sickle cell crisis pain,

• initial numeric pain intensity scale at presentation > 4,

• admission to the ED during working hours (amendment n°2-15/02/2010:from 8h to 20h), from Monday to Friday

Exclusion Criteria:

• female adult patient

• complicated sickle cell crisis or admission requirement to an ICU

• recent hospitalisation (< 10 days) for the same complaint

• previous inclusion in the study

• contraindication to anyone of the study drugs

• no medical insurance

• incompetent adult