Effectiveness of Oral Lactulose Versus Lactulose Enema in Hepatic Encephalopathy

• Status: Not yet recruiting
• Trial end date: 2023-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with chronic liver disease due to hepatitis B or C viruses, Non-alcoholic fatty liver disease, autoimmune hepatitis, wilson disease, cryptogenic hepatitis etc are prone to develop complications. Hepatic encephalopathy is one of such complications. It is graded into four types depending on severity of clinical features, which range through altered sleep pattern to coma. The current study aims to compare the effectiveness of lactulose enema with oral lactulose in time to recovery from higher grade of encephalopathy to lower grade of encephalopathy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Khyber Medical College, Peshawar
• Treatments: Lactulose

Criteria

Inclusion Criteria:

• Male and female cirrhotic patients in grades 3 or 4 of hepatic encephalopathy

• Patient with constipation as the precipitating factor will be included in the study

Exclusion Criteria:

• Patients with dehydration

• Electrolyte abnormalities

• Spontaneous bacterial peritonitis (SBP),

• Fever

• Using sedative / hypnotic medications as predisposing factors for hepatic encephalopathy