Effectiveness of Phentolamine Mesylate as a Reversing Agent for Local Anesthesia in Children
Status:
Not yet recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
Local anaesthesia is considered one of the most alarming and non-comfortable dental
procedures for children. This goes back to the persisting effect of the local anaesthesia
after finishing dental procedures. The effect of Local anaesthesia can last from 3 to 5 hours
due to the presence of vasoconstrictor. The U.S Food and Drug Administration (FDA approved
the use of phentolamine mesylate (Oraverse) in May 2008 to be used as a drug in reversing the
numbing effect of Local anaesthesia by decreasing the time needed to restore the normal
functions of the mouth