Effectiveness of Plasma Exchange in Treating With Severe Acute AQP4-Ab Positive Optic Neuritis
Status:
Recruiting
Trial end date:
2021-12-31
Target enrollment:
Participant gender:
Summary
Patients aged between 18 and 70 with acute aquaporin-4 immunoglobulin G antibodies (AQP4-IgG)
positive optic neuritis, irrespective of prior using of corticosteroids in this episode of
disease, are chosen by the physician. Patients will then be randomized to receive high dose
of intravenous corticosteroids combined with plasma exchange (PE), or merely high dose of
intravenous corticosteroids followed subsequent taper. The main outcome of visual acuity and
OCT parameters will be compared at baseline, one, three and six months after treatments, and
other assessments will also be recorded and compared. This will allow for determination on
whether additional PE plays a role in better prognosis in acute AQP4-IgG positive optic
neuritis.