Effectiveness of Platelet Rich Plasma in Wound Healing

• Status: Completed
• Trial end date: 2016-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Purpose: This prospective randomized comparative clinical study was conducted to assess the effect of platelet-rich plasma (PRP) gel on soft tissue healing and bone regeneration potential on lower third molar extraction sockets.

Methods: For the study, 50 Patients (37 male, 13 female) requiring surgical removal of a lower impacted third molar and who fulfilled the inclusion criteria were recruited. The patients were categorized into two groups, Group A and Group B. For each group 25 patients were randomly allocated. The predictor variable in Group A was the application of PRP Gel whereas in Group B had no PRP. Postoperative pain, swelling, trismus, soft tissue healing and osseous regeneration was assessed using standard methods. These outcome variables were assessed on 1, 3-, 5-, 7-, and 14-postoperative day. Patients were recalled at the 4th, 10th, and 16th postoperative week for assessment of bone healing. The data were recorded and tabulated.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Linyi People's Hospital
• Treatments: Anesthetics

Criteria

Inclusion Criteria:

• Patients age between 18 and 50 years.

• Patients who required mandibular 3rd molar extractions

• Patients had to have clinical and radiographic diagnosis of a single impacted mandibular third molar

• Radiographic diagnosis of Class II position B impaction (Pell and Gregory classification).

• Patients agree to return for recall visits

• Patients who were not experienced pain, inflammation, and infection at the operating site 7 days before the surgery.

Exclusion Criteria:

Exclusion criterion

• Patients if pregnant, lactating, or smokers or if they had systemic disease or any other medications that could interfere with healing process.

• Any antibiotic or any anti-inflammatory drug usage within a week period.

• Patients with any periapical infection or lesion associated with the third molars

• Patients with unacceptable oral hygiene