Effectiveness of Routine Nebulization of Mucolytics and Bronchodilators During Mechanical Ventilation
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this multi-center randomized controlled non-inferiority trial is to determine
the effect of a strategy using routine nebulisation of mucolytics and bronchodilators (four
times daily) as compared to a strategy using nebulisation of mucolytics or bronchodilators
only on clinical indication (i.e. occurrence of persistent thick and tenacious sputum or
bronchospasm) in mechanically ventilated intensive care patients. The investigators will
examine the effects in terms of ventilator-free days, defined as the number of days alive and
free of ventilation at day 28 after start of ventilation.
We hypothesize that a strategy that uses nebulisation of mucolytics or bronchodilators only
on clinical indication not to be inferior to a strategy using preventive nebulisation of
mucolytics or bronchodilators with regard to the number of ventilator free days in ICU
patients at day 28.
Phase:
N/A
Details
Lead Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborator:
ZonMw: The Netherlands Organisation for Health Research and Development