Effectiveness of Single Dose Fosfomycin and Single Dose Levofloxacin as Pre-urodynamic Antibiotic for UTI Prevention

• Status: Completed
• Trial end date: 2024-03-25
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this clinical trial is to compare the use of single dose fosfomycin and single dose levofloxacin as pre-urodynamic antibiotic prophylaxis for urinary tract infection prevention post-urodynamic in patients with lower urinary tract symptoms. The main question[s] it aims to answer are:

• What is the difference between the effectiveness of administering a single dose of fosfomycin and levofloxacin prior to the procedure in terms of the incidence rate of urinary tract infection (UTI) post-urodynamic examination?

• What is the incidence rate of UTI in the administration of single-dose fosfomycin and levofloxacin prior to the procedure on the incidence rate of UTI post-urodynamic examination? Participants fulfilling the inclusion criteria will be taken their history and vital signs and consume either fosfomycin or levofloxacin based on the randomisation prior to urodynamic procedure. Afterwards, participants will undergo urine analysis 4 days post urodynamic to evaluate if there's any urinary tract infection. If there is any bacteria present, the sample will be cultured to identify bacteria found in the urine.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indonesia University
• Treatments: Fosfomycin; Levofloxacin

Criteria

Inclusion Criteria:

• Male/female patients > 18 years who have indications for urodynamics

• Willing to participate in research

Exclusion Criteria:

• Allergy to levofloxacin

• Allergy to fosfomycin

• History of taking antibiotics in 1 month

• Pregnant

• Uncontrolled DM

• Use of urinary catheter

• Having a UTI before urodynamics, based on clinical symptoms and urine examination results

• Refuse to participate in research