Effectiveness of Ziprasidone for Patients With Schizophrenia

• Status: Completed
• Trial end date: 2013-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study is designed with the aim to evaluate the clinical effect of the overlapped switching to ziprasidone as well as the efficacy and safe metabolic profile of ziprasidone.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Soonchunhyang University Hospital
• Collaborator: Pfizer
• Treatments: Ziprasidone

Criteria

Inclusion Criteria:

• Male and female aged 18-55 years treated with risperidone, olanzapine, amisulpride, quetiapine and typical antipsychotics.

• Both in- and outpatients who met Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for schizophrenia or schizoaffective disorder.

• Their primary psychiatric clinician determined that they would benefit from a change in their medications, either because of suboptimal efficacy or because of side effects.

Exclusion Criteria:

• Those who are treated with medications that prolong the QTc interval.

• Those who have any other axis I DSM-IV diagnoses.

• Those who have a history of substance abuse or dependence within 1 month.

• Those who have clinically significant abnormal laboratory values or any other abnormal baseline laboratory findings considered by psychiatrists to be indicative of conditions that might affect the study results.

• Those who have a past history of hypersensitivity or intolerance to ziprasidone.

• Those who have history of clozapine use within 1 month.

• Those who participated in clinical trials within 1 month before entering the study entry.

• Those who have used depot antipsychotics within one cycle before entering the study.

• Those who are pregnant or are breast feeding.

• Those who have a immediate risk of harming self or others or history of suicide attempts in the year before the screening precluded inclusion in the study.

• The patients unable/unlikely to comprehend/follow the protocol.