Overview Effectivity and Safety of PFO Closure vs Medicine in Alleviating Migraine Status: Not yet recruiting Trial end date: 2024-12-01 Target enrollment: Participant gender: Summary Effectivity and safety of PFO closure vs medicine in alleviating migraine (SPRING): a multicenter, random, case control study Phase: Phase 3 Details Lead Sponsor: Guangdong Provincial People's HospitalTreatments: AspirinClopidogrel