Effects Magnesium Sulfate and Labetalol Infusion on Peripheral Perfusion and Pain in Nasal Surgeries
Status:
Recruiting
Trial end date:
2021-09-01
Target enrollment:
Participant gender:
Summary
One of main risk of controlled hypotension during nasal surgeries is impaired perfusion.
Peripheral perfusion of non-vital organs usually impaired earlier than vital organs. So,
evaluation of perfusion of non-vital organ is considered to be adequate measure of patient
safety during surgery.
Many hypotensive agents such as dexmedetomidine, B blockers, magnesium sulfate and
nitroglycerine had been used but we are in need to investigate its effects on peripheral
perfusion.
Postoperative pain related to nasal surgeries due to surgical trauma itself which induces the
release of inflammatory mediators from neuronal and immune cells resulting in peripheral and
central sensitization significantly affects recovery of patients. Magnesium sulfate and
labetalol have analgesic actions besides their hypotensive effects but with different
mechanisms.