Effects Of Combination Therapy Of Statin And Ascorbic Acid For Prevention Of Contrast-Induced Nephropathy

• Status: Completed
• Trial end date: 2020-01-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the benefit for statin use in prevention of of CI-AKI after computed tomography urogram (CTU).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Mansoura University
• Treatments: Ascorbic Acid; Atorvastatin

Criteria

Inclusion Criteria:

• Planned computed tomography urogram (CTU)

• Statin naive, or not on statin treatment for at least 14 day

Exclusion Criteria:

• History of liver disease or elevated serum transaminases

• History of rhabdomyolysis or elevated creatinine kinase

• History of iodinated CM use within 14 days before randomization

• History of N-acetylcysteine, metformin or nonsteroidal anti-inflammatory drugs use within 48 hours of the procedure.

• History of hypersensitivity reaction to contrast media

• Pregnancy or lactation

• Acute renal failure

• End-stage renal disease requiring dialysis

• Cardiogenic shock or pulmonary edema

• Multiple myeloma