Effects of 10 Versus 20 mL Local Anesthetic for Popliteal Plexus Block on Opioid Consumption, Pain, and Patient-Reported Outcomes After Total Knee Arthroplasty

• Status: ENROLLING_BY_INVITATION
• Trial end date: 2026-03-01

Summary

This trial aims to assess the analgesic effect of Popliteal Plexus Block (PPB) with 10 mL versus 20 mL of Bupivacain 5 mg/mL, when applied as an adjunct treatment to a multimodal analgesic regimen following primary total knee arthroplasty. We hypothesize that PPB with 20 mL of local anesthetic reduces 24-hour postoperative opioid consumption (= primary outcome) compared to 10 mL after TKA.

Secondary outcome include

• the frequency of 24-hour opioid-free analgesia
• pain intensity at rest and during mobilization
• Manual Muscle Tests and ability to mobilize with crutches six hours after end-of-surgery
• and patients reported outcomes using the Quality of Recovery 15 survey 24 hours after end-of-surgery.

Participant will:

• undergo primary total knee arthroplasty in spinal anesthesia.
• recieve a PPB with either 10 mL of Bupivacaine or 20 mL.
• recieve a multimodal analgesic regime including a Femoral Triangle Block.
• Have 10 scored morphine tablets available for self-administration within the first 24 postoperative hours after end-of-surgery.
• be examined by a physiotherapist 6 hours (1 hour) after end-of-surgery to assess pain scores, manual muscle testing of ankle and knee function, and the ability to mobilize with crutches.
• complete a survey 24 hours after end-of-surgery to assess self-administered morphine intake, pain scores, and Quality of Recovery-15.

• Phase: PHASE4

Details

• Lead Sponsor: Regionshospitalet Silkeborg
• Treatments: Bupivacaine