Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Endoscopic treatment of bleeding peptic ulcers is effective to prevent rebleeding. Adjuvant
medical treatment to increase gastric pH may further decrease rebleeding. Recent studies on
potent acid suppression by proton pump inhibitors (PPI) demonstrated the efficacy in
preventing rebleeding. Lau demonstrated that high dose intravenous infusion of omeprazole
decreased rebleeding in peptic ulcers with stigmata of recent hemorrhage.
There is little data regarding the effect of pantoprazole on bleeding peptic ulcers.
Furthermore, the optimal dose of PPI is unknown. Few studies have included measurement of
gastric pH in addition to clinical outcome.
This study compares the effect of two doses of intravenous pantoprazole with no acid
suppression in bleeding peptic ulcers after endoscopic therapy. In addition to the usual
clinical endpoints, gastric pH is monitored to study the relation of pH elevation and the
clinical outcome.