Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
Status:
Not yet recruiting
Trial end date:
2023-01-30
Target enrollment:
Participant gender:
Summary
Chronic periodontitis is an infectious disease of periodontal support tissues caused by
bacterial biofilm, which leads to inflammation and destruction of periodontal support tissues
ultimately resulting in tooth loss.In the clinic, patients with Stage III and Grade B
periodontitis are difficult to gain desired outcomes on account of deep periodontal pockets,
complicated anatomy, the removal of subgingival dental biofilms, and control of residual
inflammation. A large number of studies have indicated that the effectiveness of local
application of antibiotics as an adjunct to scaling and root planning (SRP), such as the
antimicrobial and minocycline hydrochloride could affect bacterial metabolism and inhibit
bioļ¬lm attachment particularly in terms of pocket depth reduction and attachment level gain.
However, the use of wide-spectrum antibiotics may cause some inevitable side effects
including drug resistance, pathogens and probiotics were eliminated leading to diversity of
microbiota diminished, and toothstaining. To solve the problems of antibiotics in the clinic,
antimicrobial peptides (AMPs) may be considered as an alternative to conventional antibiotics
drugs.In this randomized clinical trial, we aimed to evaluate the effects of AMPs as an
addition to SRP on clinical parameters and microbiological biofilms in patients with Stage
III and Grade B periodontitis.
Phase:
Phase 4
Details
Lead Sponsor:
Beijing Stomatological Hospital, Capital Medical University