Effects of Acetylcholine and Attention on Visual Spatial Representations in the Brain

• Status: Completed
• Trial end date: 2021-08-02
• Target enrollment: 0
• Participant gender: All

Summary

This study in, healthy human subjects using fMRI and MRS (magnetic resonance spectroscopy) characterizes, how attention and acetylcholine affect visual perception and the brain's representation of the visual environment. Levels of acetylcholine in the cerebral cortex will be enhanced by administration of donepezil, an inhibitor of acetylcholinesterase. Half the subjects will receive donepezil and other half will receive placebo.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, Berkeley

Criteria

Inclusion Criteria:

• Healthy adult individuals

Exclusion Criteria:

• Pregnancy

• Asthma/lung problems

• Certain medications, seizure

• Failure to complete Donepezil (Aricept) Contraindications Screening Sheet

• Previous long term exposure to nicotine/tobacco products, individuals with pacemakers, cosmetics, or certain metallic implants in their bodies will be excluded from experiments involving MRI recording.