Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression
Status:
Recruiting
Trial end date:
2026-12-31
Target enrollment:
Participant gender:
Summary
This is a 2x2, within-subjects, cross-over trial to test the anti-depressant effects of acute
exercise in 20 participants with bipolar depression. Participants will complete four
experimental sessions, two with an exercise challenge and two with a resting control
condition in a counterbalanced order. Participants will receive either 800mg of ibuprofen or
placebo before exercise or rest in order to test whether blocking the inflammatory response
to exercise interferes with the neural and psychological effects of exercise.