Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic
dysfunction occurs frequently and is related to a poor outcome. We have previously shown that
parameters of diastolic function significantly correlate with uric acid levels, a marker of
impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase
with allopurinol might affect diastolic function in patients with CHF.