Effects of Amantadine on Postoperative Cognitive Dysfunction

• Status: Unknown status
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Post-operative cognitive dysfunction (POCD) is a fairly well-documented clinical phenomenon. Investigators will determine whether amantadine can reduce the occurrence of POCD in elderly patients with major abdominal surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Zhiyi Zuo
• Collaborators: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University; Sun Yat-sen University
• Treatments: Amantadine

Criteria

Inclusion Criteria:

1. major elective gynecological, prostate or bladder surgery patients who are ≥ 60 years old.

2. the surgery is laparoscopic surgery and is expected to last for ≥ 2 hours under general anesthesia and the patient will stay in hospital for at least 7 days after surgery.

3. lack of serious hearing and vision impairment and be able to read so that neurobehavioral tests can be performed.

Exclusion Criteria:

1. Patients are not expected to be alive for longer than 3 months.

2. Mini-mental State Examination (MMSE) [18] score ≤ 23.

3. history of dementia, psychiatric illness or any diseases of central nervous system.

4. current use of sedatives or antidepressant.

5. alcoholism and drug dependence.

6. patients previously included in this study (for patients who have second intra-abdominal surgery during the study period).

7. difficult to follow up or patients with poor compliance.

8. uncontrolled hypertension (> 180/100 mmHg)