Effects of Anorexia Nervosa on Bone Mass in Adolescents

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study is to determine the effects of anorexia nervosa on bone mass and hormone levels in adolescents. Whether administration of estrogen, a normal hormone present during puberty, can help maintain bone development in girls with anorexia nervosa will be determined.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Massachusetts General Hospital
• Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); The Hospital for Sick Children
• Treatments: Estradiol; Estradiol 17 beta-cypionate; Estradiol 3-benzoate; Estradiol valerate; Estrogens; Medroxyprogesterone Acetate; Polyestradiol phosphate; Progesterone

Criteria

Inclusion Criteria:

• Females Only with Anorexia Nervosa and Amenorrhea 12-18 years

• Normal-weight girls 12-18 years with no past or present history of an eating disorder

Exclusion Criteria:

• Diseases affecting bone metabolism (including untreated thyroid disease, premature ovarian failure, diabetes, cancer, pituitary, renal disease or bone fracture within the past six months)

• Use of prescription medications affecting bone metabolism within three months

• Suicidality

• Psychosis

• Substance abuse

• Hematocrit <30 %

• Potassium <3.0 mmol/L

• Glucose <50 mg/dl.