Effects of Antidepressant on Postsynaptic Signal Transduction in Serotonergic System of Depressed Patients

• Status: Unknown status
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether alteration of signal transduction components after antidepressant targeting, predict antidepressant responsiveness in advance before the appearance of the drug effects until 4~6 weeks after drug administration, or represent the clinical status of depressed patients.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Samsung Medical Center
• Treatments: Antidepressive Agents; Fluoxetine; Levomilnacipran; Milnacipran; Mirtazapine; Nortriptyline; Paroxetine; Sertraline; Venlafaxine Hydrochloride

Criteria

Inclusion Criteria:

1. met the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-IV) criteria for MDD from the Department of Psychiatry, Sungkyunkwan University, Seoul, South Korea.

2. were 18 years of age or older, the existence of a unipolar major depressive episode as verified by DSM-III/IV criteria, at least 2 years after first episode onset, and agreement to informed consents

Exclusion Criteria:

• pregnancy

• significant medical conditions

• abnormal laboratory baseline values

• unstable psychiatric features (e.g, suicidal attempt)

• history of alcohol or drug dependence, seizure, neurological illness, or concomitant Axis I psychiatric disorder