Effects of Aripiprazole and Haloperidol on Mesolimbic System Functioning

• Status: Completed
• Trial end date: 2011-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The main objective is to investigate if the brain activation signature of a typical antipsychotic agent is dissociable from a newer drug with a pharmacological profile that differs from both typical and atypical antipsychotics since it is a potent partial D2 agonist. The method used to study this will be functional magnetic resonance imaging (fMRI).

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Oslo University Hospital
• Treatments: Aripiprazole; Haloperidol; Haloperidol decanoate

Criteria

Inclusion Criteria:

• Male or Female subject, 18 to 50 years of age

• Capacity to give written informed consent

• Psychiatrically healthy as determined by the MINI interview

Exclusion Criteria:

• History of head trauma resulting in loss of consciousness >30 minutes that required medical attention

• Positive screen for pregnancy or current breast feeding

• Serious, unstable medical illness, or any concomitant major medical or neurological illness as determined by history and physical exam

• Used psychotropic medication in the last two years

• Used any drugs/medications/natural product the last two weeks (contraceptives, caffeine and nicotine excluded)

• Metal implants that would preclude an MRI scan

• Clinically relevant abnormalities in the electro-cardiogram (ECG)

• Confirmed clinically significant abnormal laboratory value(s) at screening (lab screen, LFTs, haematology and urine sample will be performed)

• Any history of arterial hypertension or paroxysmal hypertensive states

• Established diagnosis of advanced arteriosclerosis

• Established diagnosis of hyperthyroidism

• Established diagnosis of glaucoma

• History of hypersensitivity to sympathomimetic amines

• History of hypersensitivity to aspirin

• Self-reported feelings of claustrophobia when in narrow environments

• Worked with metal as a grinder, welder etc.

• Lifetime history of substance dependence or abuse (except nicotine and caffeine)

• Systolic blood pressure > 140 and/or Diastolic blood pressure >90

• Body weight below 56kg or above 94kg

• History of use of antipsychotic medication