Effects of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes
Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
The fibrin network is an important component of an arterial thrombus and its structure
influences the degradation of the formed clot. A tighter and less permeable fibrin network,
which is less susceptible to fibrinolysis, is formed in patients with manifest cardiovascular
disease (CVD) or conditions associated with increased risk of atherothrombotic complications.
In a previous study we have shown reduced fibrin network permeability in patients with type 1
diabetes, which may contribute to their increased risk of CVD. Low dose aspirin treatment is
standard in management of CVD; however, the effect seems reduced in patients with diabetes.
Our previous studies have shown that aspirin treatment alters the fibrin network in
non-diabetic individuals and increases the fibrin network permeability. The effect of aspirin
on fibrin network formation in patients with diabetes is unclear.
We hypothesized that patients with type 1 diabetes might need higher doses of aspirin than
the recommended low dose (75mg) treatment to gain effects on fibrin network permeability, and
that the effects of aspirin treatment on fibrin network in these patients are influenced by
the glycemic control.