Effects of Beta-blockade on Platelet Aggregation in Acute Coronary Syndrome

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The Investigators will test the hypothesis that nonselective beta-blockers would have a more pronounced effect on platelet aggregation than selective beta-blockers in patients with acute coronary syndrome treated with dual anti platelet therapy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Federico II University
• Treatments: Adrenergic beta-Antagonists; Carvedilol; Metoprolol

Criteria

Inclusion Criteria:

• Acute Coronary Syndrome

• Current dual anti platelet treatment with acetylsalicylic acid and Ticagrelor

Exclusion Criteria:

• ongoing prasugrel, ticlopidine or clopidogrel therapy

• Creatinine Clearance < 30 ml/min/1.73mm2

• Moderate to severe anemia Hemoglobin < 10 mg/dl

• Platelet count >600000/mm3 or <150000/mm3 or hematocrit >50% or <25%

• concomitant neoplastic or immune-mediated pathologies

• severe pulmonary pathologies

• contraindication to beta blocker therapy.