Effects of Bile Acids on GLP-1 Secretion After Roux-en-Y Gastric Bypass

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the effects of bile acids on GLP-1 secretion after Roux-en-Y gastric bypass.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hvidovre University Hospital
• Collaborator: University of Copenhagen
• Treatments: Chenodeoxycholic Acid; Ursodeoxycholic Acid

Criteria

Inclusion Criteria:

• Uncomplicated RYGB performed minimum 3 months prior to the study.

• Fasting plasma glucose < 7.0mM, HbA1c < 48mmol/mol 3 months after RYGB.

Exclusion Criteria:

• Fasting plasma glucose > 7.0mM, HbA1c > 48mmol/mol 3 months after RYGB.

• Dysregulated hypothyroidism, use of antithyroid treatment.

• Late diabetic complications as retinopathy, renal insufficiency, neuropathy or previous pancreatitis.

• Complications to RYGB: Documented reactive hypoglycaemia, severe dumping (vomiting, diarrhea, severe abdominal pain after food intake).