Effects of Bisoprolol and Atenolol on Sympathetic Nervous Activity and Central Aortic Pressure in Patients With Essential Hypertension

• Status: Completed
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: All

Summary

β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent cardiovascular factors for hypertension. Hence, we analyzed the effects of bisoprolol and atenolol on SNA and CAP in hypertensive patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ruijin Hospital
• Treatments: Atenolol; Bisoprolol

Criteria

Inclusion Criteria:

• 25~65 years old

• untreated essential hypertension

• SBP 140-160mmHg & DBP 90-100mmHg

• Sinus rhythm

• Resting heart rate >70bpm

• Can give written informed consent

Exclusion Criteria:

• Atrial Fibrillation (AF)/ Sick Sinus Syndrome (SSS)/ atrioventricular block 2-3 grade(AVBⅡ-Ⅲ) without pacemaker

• Bradyarrhythmia/ hypotensive

• Unstable Angina Pectoris (UAP)/AMI/ HF (NYHA class III - IV)

• Uncontrolled diabetes mellitus (DM)

• Bronchial asthma

• Gastro-intestinal ulcer or skin ulcer

• Liver dysfunction/ renal impairment

• Treated with CCB (Calcium antagonists) ( except amlodipine) or other beta blocker.

• Glaucoma

• Known allergic/ intolerance to beta blocker

• Pregnant or lactating women

• Participation in another clinical study within the last 3 months

• Legal incapacity or limited legal capacity