Cannabidiol (CBD) is a phytocannabinoid that is one of 113 identified cannabinoids in the
cannabis plant. It is derived from the hemp plant, and may treat conditions like pain,
insomnia, and anxiety. CBD is a critical component of medical marijuana and does not cause
the "high" typically associated with cannabis. According to the World Health Organization,
CBD has shown no evidence of abuse or dependence potential. However, to the investigator's
knowledge, there have not been many acute clinical studies to characterize the effects of CBD
in the brain. Despite the rapid influx in CBD readily available to the public, very little is
known about such effects. Some studies have shown alterations in resting state connectivity,
while others have described changes in specific regions of the brain, or in networks
associated with various cognitive functions. For example, CBD has been shown to increase
fronto-striatal connectivity and reduce mediotemporal-prefrontal connectivity, suggesting
that CBD may affect brain regions involved in salience processing. Unfortunately, few studies
have examined CBD in isolation. Additionally, several studies have suggested that CBD may
have a neuroprotective effect when it comes to individuals at high risk for psychiatric
conditions. In this study, the investigators propose an acute administration, double-blind,
placebo-controlled study in which 100% THC-free CBD will be compared to placebo
(https://foliumbiosciences.com/). To the investigator's knowledge, the acute effects of this
specific product have not been tested. Specifically, the investigators will examine: 1) the
neurometabolic and neurophysiological effects of CBD compared to placebo and 2) the
behavioral effects of CBD on measures of working memory and response inhibition. Participants
will be recruited to take encapsulated, THC-free CBD provided by Folium Biosciences, in which
they will have a pre- and post-ingestion scan. Each participant will have a 72-hour washout
period after which they will be asked to come back for a placebo scan (however, the order
will be counterbalanced so that equal numbers of participants will receive placebo/supplement
and supplement/placebo). Individuals will be randomized into the supplementation group, as
well as the order.