Effects of Carbon Monoxide Breathing on Blood Vessel Function

• Status: Completed
• Trial end date: 2019-03-01
• Target enrollment: 0
• Participant gender: All

Summary

In healthy young adults 18-39 years of age, the investigators will determine if intermittent inhalation a 0.1% CO, from a 1-liter bag once every minute for 30-40 minutes, at a level that approaches the CO boost with hookah smoking, augments endothelial function, thus implicating CO as the major endothelial vasodilator substance in hookah smoke.

Rationale: Our group has demonstrated (PRO36547) that in contrast to cigarette smoking, hookah smoking (tobacco heated with charcoal) acutely augments, rather than impairs, brachial artery FMD. Importantly, our data strongly implicate-but do not prove-that the augmentation in FMD is caused by CO. Therefore; the investigators would like to extend the scientific priority of this work by directly investigating cause and effect of CO breathing (similar levels than ones obtained after hookah smoking) on brachial artery FMD.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cedars-Sinai Medical Center
• Treatments: Carbon Monoxide

Criteria

Inclusion Criteria:

• 18-39 years of age

Exclusion Criteria:

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease

• BP > 140/90 mmHg

• BMI <18.5 or > 30 kg·m2

• Resting heart rate > 100 beats/min

• Taking prescription medication

• Hemoglobin levels < 11.6 g/dL

• Total cholesterol > 240 or HDL < 36

• Fasting glucose >100 mg/dL or <60 mg/dL

• Bilirubin >1.2 mg/dL; albumin < 3.5 or > 5.5 g/dL; alkaline phosphatase (alk phos) >125 IU/L; alanine aminotransferase (ALT) > 45 U/L; aspartate aminotransferase (AST) > 35 U/L

• Positive (+) toxicology screen

• Pregnant