Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression
Status:
Terminated
Trial end date:
2015-03-01
Target enrollment:
Participant gender:
Summary
This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and
cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the
relationship between vascular disease and depression in older adults. The long-term objective
of this line of research is to: A) determine the relationship between vascular reactivity,
cerebral hypoperfusion and the persistence of late-life depression and B) determine if
improving cerebral perfusion with angiotensin receptor blockers (ARBs) improves depression
outcomes.