Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke
Status:
Completed
Trial end date:
2019-02-14
Target enrollment:
Participant gender:
Summary
This study, E-COMPASSII is a phase IV clinical trial designed as a multicenter, randomized,
double-blind, placebo-controlled, parallel-group study. This study will enroll 80 subacute
stroke patients with severe motor involvement. Primary objective is to demonstrate the
efficacy of porcine brain peptide to improve motor recovery measured by the improvement ratio
of Fugl-Meyer assessment ((score of FMA after 3 weeks - score of FMA at baseline) / score of
FMA at baseline) in patients with subacute stroke. Secondary objectives are to evaluate the
safety profile of cerebrolysin and to test the hypothesis that subacute stroke patients with
severe motor involvement randomized to administration of Cerebrolysin combined with
rehabilitation for 3 weeks show better outcome on global function (Korean version Modified
Barthel Index, K-MBI), severity of stroke (National Institute of Health Stroke Scale, NIHSS),
cognitive function (Korean Version of Mini-Mental State Exam, K-MMSE; Korean version Montreal
Cognitive Assessment, K-MoCA), upper limb function (Action Research Arm Test, ARAT; Box and
block test, B&B) and neuroplasticity measure (resting-state functional MRI(rsfMRI), diffusion
tensor image(DTI), and motor evoked potential(MEP)) at 3 months after stroke.