Effects of Changing Intestinal Transit Time on Gut Microbial Composition and Metabolism

• Status: Recruiting
• Trial end date: 2030-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate how a short versus a long transit time impacts the gut microbiome's response to a high-fiber and a low-fiber diet, respectively. Such insights could help us understand personal responses to diets and be a first step towards personalized dietary recommendations targeting the gut microbiome.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Copenhagen
• Collaborators: KU Leuven; Technical University of Denmark; University of Minnesota
• Treatments: Laxatives

Criteria

Inclusion Criteria:

• 18.5-30.0 kg/m2 BMI

• Self-reported ≤3.5 spontaneous bowel movements per week

• Willing to collect urine and stool samples at home and able to temporarily store them in their own freezer in a provided container.

• Willing to eat the foods provided.

• Owns a smartphone (iOS 11.0 and later or Android 5.0 and up) with access to the internet.

Exclusion Criteria:

• Pregnant or lactating women.

• Diagnosis of irritable bowel syndrome (IBS), small intestinal bacterial overgrowth (SIBO), inflammatory bowel diseases (IBD), Gastrointestinal obstruction, or Ischemic colitis

• Diagnosed constipation according to the ROME IV criteria

• Intake of antibiotics ˂ 1month, or any medication that can affect the outcomes of the study

• Regular use of diarrhea inhibitors or laxatives

• Dysphagia

• Any chronic disease that can affect the outcomes of the study or pose a risk when consuming Movicol

• Intake of medications potentially altering gastric pH (proton pump inhibitors, histamine receptor antagonists, antacids)

• Intake of medications potentially altering the gastrointestinal motility (prokinetics, antiemetic agents, anti-cholinergic agents, narcotic analgetics, nonsteroidal anti-inflammatory drugs, and peroral glucocorticoids)

• Concurrent participation in another trial

• Any condition that makes the project responsible researcher to doubt the feasibility of the volunteer´s participation