Effects of Cholecalciferol Supplementation in Patients With Chronic Heart Failure and LOw vITamind D Levels

• Status: Unknown status
• Trial end date: 2012-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether cholecalciferol supplementation in patients with chronic heart failure and low vitamin D levels improves:

1. performance at six minutes walking test

2. echocardiographic parameters

3. neurohormonal imbalance

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Azienda Unita' Sanitaria Locale Di Modena
• Collaborator: Abiogen Pharma
• Treatments: Cholecalciferol; Vitamin D

Criteria

Inclusion Criteria:

• Heart failure diagnosis according to European Society of Cardiology Guideline criteria

• Age > 60 years old

• 25(OH) Vitamin D level < 30 ng/ml

• Clinical and therapeutic stability for one month (NYHA class II or III)

Exclusion Criteria:

• Chronic use of anticonvulsants or barbiturates, steroids, thiazides, aluminium or magnesium, colestipol or cholestyramine

• Glomerular filtration rate lower than 30 ml/min/1.73 m2 according to MDRD equation

• Nephrolitiasis, Sarcoidosis or hypercalcemia

• Recent (three months) acute coronary syndrome or stroke or major vascular surgery

• Reduced life expectancy due to other diseases (active neoplasms, liver cirrhosis...)