Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease

• Status: Completed
• Trial end date: 2013-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The object of this research is to test the effectiveness of Coenzyme Q10 (CoQ10) on symptoms of weakness, fatigue, and pain in persons with Charcot-Marie-Tooth disease (CMT).In this study we also intend to examine the impact of daily supplementation on overall quality of life.We are also interested in identifying any differences in serum ratios of CoQ10 in the oxidized and reduced forms.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Memorial Medical Center
• Collaborator: United States Department of Defense
• Treatments: Coenzyme Q10; Ubiquinone

Criteria

Inclusion Criteria:

• Subjects must have a diagnosis of CMT, confirmed by review of medical records by the study physician

• Subjects can be of either gender

• Subjects must be between the ages of 18 and 75

• Subjects must be able to complete all assessments at the designated time intervals

• Subjects must review and sign the informed consent statement according to Conemaugh Memorial Medical Center's (CMMC) Institutional Review Board (IRB) guidelines

• Subjects must receive approval from their primary care physician (PCP) to enroll in the study

• Regarding weakness, fatigue, and pain, subjects must experience at least two of the three symptoms on most days over the past month

• Regarding weakness, fatigue, and pain, subjects must report experiencing maximum levels of >/= 3.0 centimeters (cm) on the 10 cm visual analog scale (VAS) for any two of the three symptoms over the past month

• Female subjects must be willing to practice stable birth control during involvement in the study

• Subjects must agree to be randomized

Exclusion Criteria:

• Subjects having another general medical condition, which might confound the assessment of weakness, fatigue, and pain due to CMT

• Subjects taking warfarin or Coumadin

• Subjects who are pregnant, verified by a urine pregnancy test*

• Subjects having a cognitive impairment scoring < 20 on the Mini-Mental State Exam

• Subjects who are currently using CoQ10 supplementation or have used it in the past 6 months

• Subjects with a history of chronic liver disease or other condition causing malabsorption

• Drug intake that could modify lipid absorption (such as statins)

• Subjects who consume >3 alcoholic drinks per day on more than one occasion per month

• Subjects with abnormal liver function tests as defined through a Hepatic -Function Panel or a Liver Function Panel

• Women of childbearing age who have had at least one menstrual cycle within the past 12 months and who have not undergone a sterilization procedure will undergo a urine pregnancy test at visits 1-10 regardless of group assignment in order to maintain the single blind. The urine samples will be processed at CMMC's lab