Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
Status:
Completed
Trial end date:
2021-04-13
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT)
inhibitor tolcapone, relative to placebo, reduces alcohol drinking and alcohol cue-elicited
brain activation and increases brain activation associated with cognitive control as a
function of a participant's genotype at a polymorphism in the COMT gene.
Phase:
Phase 2
Details
Lead Sponsor:
Medical University of South Carolina
Collaborator:
National Institute on Alcohol Abuse and Alcoholism (NIAAA)