Effects of Corticorelin Administration on Dopamine Transmission, Craving, and Mood in Cocaine Dependence

• Status: Completed
• Trial end date: 2016-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will, in a sample of cocaine-dependent and healthy control subjects, administer corticorelin and compare dopamine release between groups. Dopamine release will be measured using PET neuroimaging with the radiotracer [11C]-(+)-PHNO.

• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Centre for Addiction and Mental Health
• Treatments: Adrenocorticotropic Hormone; Cocaine; Corticotropin-Releasing Hormone; Dopamine; Dopamine Agents; Hormones

Criteria

Inclusion Criteria:

• Sign and date informed consent

• Willing and able to complete trial as described in the protocol

• Psychiatrically healthy (as per diagnostic interview) except for cocaine dependence in cocaine users and nicotine dependence in both groups

• Mentally healthy

• Medically healthy (as per medical exam) with no current use of medications that may interfere with hormone activity or psychological measurements

Exclusion Criteria:

• Axis I psychiatric disorder (as per diagnostic interview), or medical condition that might interfere with participation in the study (as per medical exam)

• Exposure to radiation in the last 12 months exceeding the amount permissible by the CAMH PET centre

• Have received synthetic glucocorticoid or exogenous steroid therapy within one month of testing

• Exceed normal body weight

• If female: pregnancy or breast-feeding

• Metal implants or paramagnetic objects contained within the body

• Claustrophobia