Overview

Effects of Dexmedetomidine Premedication on Emergence Agitation After Strabismus Surgery in Children

Status:
Completed

Trial end date:
2014-08-01

Target enrollment:
0

Participant gender:
All

Summary

Sevoflurane is frequently used for pediatric anesthesia because it has low pungency and rapid onset and offset of action.The reported incidence of emergence agitation (EA) following sevoflurane anesthesia varies from 10-80%. Despite its spontaneous resolution, EA is still considered as a potentially serious complication because of the risks of self-injury, and because of the stress caused to both caregivers and families. Dexmedetomidine, an Alpha2-adrenoceptor agonist with sedative, analgesic, and anxiolytic actions, has been used in pediatric populations.Several prospective clinical trials in children have shown that dexmedetomidine significantly reduces the incidence of EA prior to recovery from sevoflurane anesthesia. However, the effect of dexmedetomidine premedication on emergence agitation has not been fully evaluated. The purpose of the present study was to verify the hypothesis that intranasal premedication with dexmedetomidine is effective in reducing emergence agitation after sevoflurane anaesthesia.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Yao Yusheng

Collaborator:

West China Hospital

Treatments:

Anesthetics
Dexmedetomidine
GABA Modulators
Midazolam

Criteria

Inclusion Criteria:

- aged2-6 yr, with American Society of Anesthesiologists physical status I or II,
scheduled to undergo strabismus surgery during general anesthesia

Exclusion Criteria:

- mental disease, neurologic disease, treatment with sedatives, full stomach, or
indication for rapid sequence induction.