Effects of Dexmedetomidine on Microcirculation of Kidney Transplant Recipient
Status:
Completed
Trial end date:
2019-07-01
Target enrollment:
Participant gender:
Summary
The microcirculation is altered in acute kidney injury and chronic kidney disease. The
microcirculation is poor in end-stage renal disease patients receiving hemodialysis. Kidney
transplant can improve the life quality of these patients. However, surgical stress and
inflammatory response may cause microcirculatory dysfunction and intestinal injury. Moreover,
the transplanted kidney would suffer from the ischemia and reperfusion injury, and it may
result in acute kidney injury. In ischemia and reperfusion injury animal model,
dexmedetomidine has been proven to attenuate kidney and intestinal injury. In our previous
study of surgical stress and pain stimulation rat model, we found that dexmedetomidine
attenuate the intestinal microcirculatory dysfunction. In patients receiving coronary artery
bypass graft surgery, dexmedetomidine increases urine output and decreases postoperative
serum level of neutrophil gelatinase-associated lipocalin.
This study aims to investigate whether perioperative dexmedetomidine infusion may attenuate
microcirculatory dysfunction, kidney injury, and intestinal injury for patients undergoing
kidney transplant.