Effects of Dexmedetomidine on Modulation of Perioperative Blood Glucose and Related Hormones
Status:
Completed
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
The investigators aimed to explore effects of dexmedetomidine on modulation of perioperative
blood glucose and relevant hormone during the general anesthesia with surgery time ≥ 4 hours,
and the effects on postoperative complications. 75 participants (American Society of
Anesthesiologists grades I or II, of both sexes,aged 40-80 yr,with BMI of 18.5-27 kg/m2)
scheduled for elective surgery under general anesthesia with surgery time ≥ 4 hours were
enrolled in this study. The participants were divided into four groups: group C (control
saline group, no dexmedetomidine use), group D1 (dexmedetomidine loading dose 1 mcg/kg,
maintenance dose 0.25 mcg/kg/h), group D2 (dexmedetomidine loading dose 1 mcg/kg, maintenance
dose 0.5 mcg/kg/h).10 minutes before anesthesia induction, all participants were
administrated with dexmedetomidine 1 μg/kg/min.At the beginning of induction, dexmedetomidine
was changed to corresponding maintenance dose in each group. Blood samples were taken at the
beginning of dexmedetomidine (T0), the beginning of skin incision (T1), 1 h after skin
incision (T2), the end of the surgery (T3) and 1 h after patient transfer to PACU (T4) for
the value of blood glucose,lactate and relevant hormones. Also, investigators also record the
total amount of propofol and sufentanil at the end of surgery,and the complications within 24
h after the surgery.