Effects of Dexmedetomidine on the Liver Injury After Hepatectomy
Status:
Completed
Trial end date:
2017-01-26
Target enrollment:
Participant gender:
Summary
To investigate whether dexmedetomidine reduce liver injury after hepatectomy. During
hepatectomy, surgeons always took inflow occlusion to reduce blood loss with Pringle
maneuver. A few clinical studies had shown dexmedetomidine could reduce ischaemia/reperfusion
(IR) injury caused by the secretion of reactive oxygen species and inflammatory cytokines.
Glutathione-S-transferase (GST) was a sensitive and specific marker for hepatic injury in
several studies before. So the investigator decided to use it as the primary endpoint.
Besides, in our center, there are some liver resection surgeries that didn't need occlusion.
So it can serve the best placebo for determine the the actual effect of dexmedetomidine on
the IR injury in further subgroup analysis.