Effects of Dexmedetomidine on the Liver Injury After Hepatectomy

• Status: Completed
• Trial end date: 2017-01-26
• Target enrollment: 0
• Participant gender: All

Summary

To investigate whether dexmedetomidine reduce liver injury after hepatectomy. During hepatectomy, surgeons always took inflow occlusion to reduce blood loss with Pringle maneuver. A few clinical studies had shown dexmedetomidine could reduce ischaemia/reperfusion (IR) injury caused by the secretion of reactive oxygen species and inflammatory cytokines. Glutathione-S-transferase (GST) was a sensitive and specific marker for hepatic injury in several studies before. So the investigator decided to use it as the primary endpoint. Besides, in our center, there are some liver resection surgeries that didn't need occlusion. So it can serve the best placebo for determine the the actual effect of dexmedetomidine on the IR injury in further subgroup analysis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chinese PLA General Hospital
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) I~III

• selected to have hepatectomy in our hospital, Child-Pugh A

• patient's consent

Exclusion Criteria:

• refusing to attend or attending in other clinical study

• having severe cardio-pulmonary disease, ejection fraction (EF)<40%, having cardiac infarction in recent three months, chronic obstructive pulmonary disease (COPD) (PaO2<60mmHg)

• pregnant or lactating women

• having neuropsychiatric disorders

• emergent surgeries，hemorrhage shock，

• rupture and hemorrhage of liver tumor