Effects of Dexmedetomidine vs Propofol in Patients With Intra-abdominal Sepsis
Status:
Completed
Trial end date:
2021-04-10
Target enrollment:
Participant gender:
Summary
Sepsis is defined as systemic response to infection ,and it is a main problem in ICU and
despite advance in supportive care, the mortality rate in patients with severe sepsis
continues to exceed 30% [Bone RC 1993].The effects of bacterial invasion of body tissues
result from combined actions of enzymes and toxins produced by micro-organisms themselves and
by a network of proinflammatory mediators and cytokines as tumour necrosis factor α and
interleukin 6 which are overexpressed after various noxious insults[P.Delong et al. 2006],[
Yealy et al. 2014].
the patients who are subjected to abdominal surgery in order to treat the cause
surgically,and many of these surgical procedures are lengthy and are at risk for either
pre-operatively or post-operatively with steady increase in intra-abdominal pressure(IAP)
[Malbrain ML et al. 2007] Intra-abdominal hypertension (IAH) is defined as IAP equal to or
greater than 12 mmHg whereas abdominal compartment syndrome (ACS) is defined as IAP greater
than 20 mmHg, abdominal perfusing pressure (APP) is used to predict prognosis of both IAH and
ACS [Malbrain ML et al. 2006].
The choice for using a sedative agent in ICU for mechanically ventilated patients
post-operatively is therefore a crucial one as these patients are under hyperstress state and
often require drugs for sedation and analgesia[ Chanques G et al. 2006].
Analgesics and sedation agents have clearly been shown to alter cellular function and other
mediators of immune system with wide range of immune modulation ,ranging from
immunosuppressive effects to significant anti-inflammatory effects during endotoxaemia[
Taniguchi et al. 2004] Also sedation and /or analgesia have the potential to reduce IAP
through improvement of abdominal wall compliance.
Although propofol and dexmedetomidine are used for sedation in ICU there are limited data on
their effects on inflammatory responses and IAP in septic patients.
In clinical practice, septic patients treated with dexmedetomidine have shorter time on the
ventilator as compared with those treated with lorazepam, a benzodiazepine and this
beneficial effect of dexmedetomidine is more pronounced in septic patients than in nonseptic
patients. This outcome may be partly the result of dexmedetomidine induced reduction in
pulmonary inflammatory mediators and lung tissue damage.[ M. Ueki et al. 2014] Midazolam is
known to inhibit certain aspects of the immune function. It was suggested that
benzodiazepines bind to specific receptors on macrophages and inhibit their capacity to
produce IL-1, IL-6, and TNFα.
Propofol, nowadays, has become a preferred sedative in ICU because it offers advantages over
benzodiazepines in terms of lack of accumulation, quick onset, easy adjustment, and fast
recovery after discontinuation. [ Jacobi J et al. 2002]